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1

[Methods in Enzymology] DNA Repair Enzymes: Structure, Biophysics, and Mechanism Volume 592 || DNA-PKcs, Allostery, and DNA Double-Strand Break Repair

Chirgadze, Dimitri Y.

Year:

2017

Language:

english

File:

PDF, 2.64 MB

english, 2017

2

Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining

Ochi, Takashi, Sibanda, Bancinyane Lynn, Wu, Qian, Chirgadze, Dimitri Y., Bolanos-Garcia, Victor M., Blundell, Tom L.

Journal:

Journal of Nucleic Acids

Year:

2010

Language:

english

File:

PDF, 8.83 MB

english, 2010

3

Nucleophile Selectivity of Chorismate-Utilizing Enzymes

Olivier Kerbarh, Alessio Ciulli, Dimitri Y. Chirgadze, Tom L. Blundell, Chris Abell

Journal:

Year:

2007

Language:

english

File:

PDF, 113 KB

english, 2007

4

Inhibition of Mycobacterium tuberculosis Pantothenate Synthetase by Analogues of the Reaction Intermediate

Alessio Ciulli, Duncan E. Scott, Michiyo Ando, Fernando Reyes, S. Adrian Saldanha, Kellie L. Tuck, Dimitri Y. Chirgadze, Tom L. Blundell, Chris Abell

Journal:

Year:

2008

Language:

english

File:

PDF, 497 KB

english, 2008

5

Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis

Bojana Popovic, Xiao Tang, Dimitri Y. Chirgadze, Fanglu Huang, Tom L. Blundell, Jonathan B. Spencer

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2006

Language:

english

File:

PDF, 620 KB

english, 2006

6

Crystal structure of the β-chain of human hepatocyte growth factor-like/macrophage stimulating protein

Federico Carafoli, Dimitri Y. Chirgadze, Tom L. Blundell, Ermanno Gherardi

Journal:

Year:

2005

Language:

english

File:

PDF, 730 KB

english, 2005

7

10.1038/4947

Gherardi, Ermanno, Chirgadze, Dimitri Y., Hepple, Jonathan P., Zhou, Hongjun, Byrd, R. Andrew, Blundell, Tom L.

Journal:

Natural Structural Biology

Year:

1999

Language:

english

File:

PDF, 835 KB

english, 1999

8

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

Sibanda, Bancinyane L., Chirgadze, Dimitri Y., Blundell, Tom L.

Journal:

Year:

2009

Language:

english

File:

PDF, 902 KB

english, 2009

9

Nanostructured films from hierarchical self-assembly of amyloidogenic proteins

Knowles, Tuomas P. J., Oppenheim, Tomas W., Buell, Alexander K., Chirgadze, Dimitri Y., Welland, Mark E.

Journal:

Nature Nanotechnology

Year:

2010

Language:

english

File:

PDF, 527 KB

english, 2010

10

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

Li, Yi, Chirgadze, Dimitri Y, Bolanos-Garcia, Victor M, Sibanda, Bancinyane L, Davies, Owen R, Ahnesorg, Peter, Jackson, Stephen P, Blundell, Tom L

Journal:

The EMBO Journal

Year:

2007

Language:

english

File:

PDF, 515 KB

english, 2007

11

Asymmetry in the Multiprotein Systems of Molecular Biology

Tom L. Blundell, Victor Bolanos-Garcia, Dimitri Y. Chirgadze, Nicholas J. Harmer, Thomas Lo, Luca Pellegrini, B. Lynn Sibanda

Journal:

Structural Chemistry

Year:

2002

Language:

english

File:

PDF, 642 KB

english, 2002

12

Snapshot of Protein Structure Evolution Reveals Conservation of Functional Dimerization through Intertwined Folding

Dimitri Y Chirgadze, Mykhaylo Demydchuk, Marion Becker, Stephen Moran, Massimo Paoli

Journal:

Year:

2004

Language:

english

File:

PDF, 268 KB

english, 2004

13

Knowledge-Based Real-Space Explorations for Low-Resolution Structure Determination

Nicholas Furnham, Andrew S. Doré, Dimitri Y. Chirgadze, Paul I.W. de Bakker, Mark A. DePristo, Tom L. Blundell

Journal:

Year:

2006

Language:

english

File:

PDF, 395 KB

english, 2006

14

The Crystal Structure of the N-Terminal Region of BUB1 Provides Insight into the Mechanism of BUB1 Recruitment to Kinetochores

Victor M. Bolanos-Garcia, Tomomi Kiyomitsu, Sheena D'Arcy, Dimitri Y. Chirgadze, J. Günter Grossmann, Dijana Matak-Vinkovic, Ashok R. Venkitaraman, Mitsuhiro Yanagida, Carol V. Robinson, Tom L. Blunde

Journal:

Year:

2009

Language:

english

File:

PDF, 2.20 MB

english, 2009

15

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

Victor M. Bolanos-Garcia, Tiziana Lischetti, Dijana Matak-Vinković, Ernesto Cota, Pete J. Simpson, Dimitri Y. Chirgadze, David R. Spring, Carol V. Robinson, Jakob Nilsson, Tom L. Blundell

Journal:

Year:

2011

Language:

english

File:

PDF, 1.37 MB

english, 2011

16

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

Victor M. Bolanos-Garcia, Tiziana Lischetti, Dijana Matak-Vinković, Ernesto Cota, Pete J. Simpson, Dimitri Y. Chirgadze, David R. Spring, Carol V. Robinson, Jakob Nilsson, Tom L. Blundell

Journal:

Year:

2011

Language:

english

File:

PDF, 144 KB

english, 2011

17

Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

Takashi Ochi, Qian Wu, Dimitri Y. Chirgadze, J. Günter Grossmann, Victor M. Bolanos-Garcia, Tom L. Blundell

Journal:

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

18

Structure of an Xrcc4–DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode

Andrew S. Doré, Nicholas Furnham, Owen R. Davies, Bancinyane L. Sibanda, Dimitri Y. Chirgadze, Stephen P. Jackson, Luca Pellegrini, Tom L. Blundell

Journal:

Year:

2006

Language:

english

File:

PDF, 569 KB

english, 2006

19

Crystal Structures of Yersinia enterocolitica Salicylate Synthase and its Complex with the Reaction Products Salicylate and Pyruvate

Olivier Kerbarh, Dimitri Y. Chirgadze, Tom L. Blundell, Chris Abell

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 723 KB

english, 2006

20

Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation

Dimitri Y Chirgadze, Jonathan Hepple, R.Andrew Byrd, R Sowdhamini, Tom L Blundell, Ermanno Gherardi

Journal:

Year:

1998

Language:

english

File:

PDF, 253 KB

english, 1998

21

A New Crystal Form of the NK1 Splice Variant of HGF/SF Demonstrates Extensive Hinge Movement and Suggests That the NK1 Dimer Originates by Domain Swapping

Keiichi Watanabe, Dimitri Y. Chirgadze, Daniel Lietha, Hugo de Jonge, Tom L. Blundell, Ermanno Gherardi

Journal:

Journal of Molecular Biology

Year:

2002

Language:

english

File:

PDF, 241 KB

english, 2002

22

Expanding the Solvent Chemical Space for Self-Assembly of Dipeptide Nanostructures

Mason, Thomas O., Chirgadze, Dimitri Y., Levin, Aviad, Adler-Abramovich, Lihi, Gazit, Ehud, Knowles, Tuomas P. J., Buell, Alexander K.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.16 MB

english, 2014

23

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

De Genst, Erwin, Chan, Pak-Ho, Pardon, Els, Hsu, Shang-Te D., Kumita, Janet R., Christodoulou, John, Menzer, Linda, Chirgadze, Dimitri Y., Robinson, Carol V., Muyldermans, Serge, Matagne, André, Wyns,

Journal:

Journal of Physical Chemistry B

Year:

2013

Language:

english

File:

PDF, 4.73 MB

english, 2013

24

5-Formylcytosine alters the structure of the DNA double helix

Raiber, Eun-Ang, Murat, Pierre, Chirgadze, Dimitri Y, Beraldi, Dario, Luisi, Ben F, Balasubramanian, Shankar

Journal:

Nature Structural and Molecular Biology

Year:

2014

Language:

english

File:

PDF, 1.88 MB

english, 2014

25

Crystal Structure of the TSH Receptor in Complex with a Thyroid-Stimulating Autoantibody

Sanders, Jane, Chirgadze, Dimitri Y., Sanders, Paul, Baker, Stuart, Sullivan, Andrew, Bhardwaja, Anshu, Bolton, Jane, Reeve, Magnus, Nakatake, Nobuhiro, Evans, Michele, Richards, Tonya, Powell, Michae

Journal:

Year:

2007

Language:

english

File:

PDF, 5.64 MB

english, 2007

26

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors

Blaszczyk, Michal, Harmer, Nicholas J., Chirgadze, Dimitri Y., Ascher, David B., Blundell, Tom L.

Journal:

Progress in Biophysics and Molecular Biology

Year:

2015

Language:

english

File:

PDF, 2.45 MB

english, 2015

27

Structure of a Single-Chain Fv Bound to the 17 N-Terminal Residues of Huntingtin Provides Insights into Pathogenic Amyloid Formation and Suppression

De Genst, Erwin, Chirgadze, Dimitri Y., Klein, Fabrice A.C., Butler, David C., Matak-Vinković, Dijana, Trottier, Yvon, Huston, James S., Messer, Anne, Dobson, Christopher M.

Journal:

Journal of Molecular Biology

Year:

2015

Language:

english

File:

PDF, 1.57 MB

english, 2015

28

Protein-Protein Interactions in Receptor Activation and Intracellular Signalling

Blundell, Tom L., Burke, David F., Chirgadze, Dimitri, Dhanaraj, Venugopal, Hyvönen, Marko, Innis, C. Axel, Parisini, Emilio, Pellegrini, Luca, Sayed, Muhammed, Sibanda, B. Lynn

Journal:

Biological Chemistry

Year:

2000

Language:

english

File:

PDF, 363 KB

english, 2000

29

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

Thebault, Philippe, Chirgadze, Dimitri Y., Dou, Zhen, Blundell, Tom L., Elowe, Sabine, Bolanos‑Garcia, Victor M.

Journal:

Biochemical Journal

Year:

2012

Language:

english

File:

PDF, 1.40 MB

english, 2012

30

Crystal structure of the PepSY-containing domain of the YpeB protein involved in germination of bacillus spores

Üstok, Fatma Işık, Chirgadze, Dimitri Y., Christie, Graham

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2015

Language:

english

File:

PDF, 433 KB

english, 2015

31

Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis

Rituparna Sinha Roy, Shivani Soni, Rania Harfouche, Pooja R. Vasudevan, Oliver Holmes, Hugo de Jonge, Arthur Rowe, Abhimanyu Paraskar, Dirk M. Hentschel, Dimitri Chirgadze, Tom L. Blundell, Ermanno Gh

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.77 MB

english, 2010

32

Structural and functional analysis of SleL, a peptidoglycan lysin involved in germination of B acillus spores

Üstok, Fatma Işık, Chirgadze, Dimitri Y., Christie, Graham

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2015

Language:

english

File:

PDF, 879 KB

english, 2015

33

The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination

Al-Riyami, Bahja, Üstok, Fatma Işık, Stott, Katherine, Chirgadze, Dimitri Y., Christie, Graham

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2016

Language:

english

File:

PDF, 1.16 MB

english, 2016

34

High-resolution crystal structure of the human Notch 1 ankyrin domain

Ehebauer, Matthias T., Chirgadze, Dimitri Y., Hayward, Penny, Martinez Arias, Alfonso, Blundell, Tom L.

Journal:

Biochemical Journal

Year:

2005

Language:

english

File:

PDF, 932 KB

english, 2005

35

Non-homologous end-joining partners in a helical dance: structural studies of XLF–XRCC4 interactions

Wu, Qian, Ochi, Takashi, Matak-Vinkovic, Dijana, Robinson, Carol V., Chirgadze, Dimitri Y., Blundell, Tom L.

Journal:

Biochemical Society Transactions

Year:

2011

Language:

english

File:

PDF, 739 KB

english, 2011

36

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

Sibanda, Bancinyane L., Chirgadze, Dimitri Y., Ascher, David B., Blundell, Tom L.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.63 MB

english, 2017

37

Amyloid-like fibrils from an α-helical transmembrane protein

Stroobants, Karen, Kumita, Janet Reiko, Harris, Nicola, Chirgadze, Dimitri, Dobson, Christopher M., Booth, Paula J., Vendruscolo, Michele

Journal:

Year:

2017

Language:

english

File:

PDF, 2.74 MB

english, 2017

38

Zn(II) mediates vancomycin polymerization and potentiates its antibiotic activity against resistant bacteria

Zarkan, Ashraf, Macklyne, Heather-Rose, Chirgadze, Dimitri Y., Bond, Andrew D., Hesketh, Andrew R., Hong, Hee-Jeon

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.33 MB

english, 2017

39

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain

DiCara, Danielle M., Chirgadze, Dimitri Y., Pope, Anthony R., Karatt-Vellatt, Aneesh, Winter, Anja, Slavny, Peter, van den Heuvel, Joop, Parthiban, Kothai, Holland, Jane, Packman, Len C., Mavria, Geor

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 3.13 MB

english, 2017

40

Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa

Crousilles, Audrey, Dolan, Stephen K, Brear, Paul, Chirgadze, Dimitri Y, Welch, Martin

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 1.92 MB

english, 2018

41

Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways

Wu, Qian, Liang, Shikang, Ochi, Takashi, Chirgadze, Dimitri Y., Huiskonen, Juha T., Blundell, Tom L.

Journal:

Progress in Biophysics and Molecular Biology

Year:

2019

Language:

english

File:

PDF, 1.82 MB

english, 2019

42

Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways

Wu, Qian, Liang, Shikang, Ochi, Takashi, Chirgadze, Dimitri Y., Huiskonen, Juha T., Blundell, Tom L.

Journal:

Progress in Biophysics and Molecular Biology

Year:

2019

File:

PDF, 1.82 MB

2019

43

The Influence of Pathogenic Mutations in Î±-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

Ruggeri, Francesco Simone, Flagmeier, Patrick, Kumita, Janet R., Meisl, Georg, Chirgadze, Dimitri Y., Bongiovanni, Marie N., Knowles, Tuomas P.J., Dobson, Christopher M.

Journal:

Year:

2020

File:

PDF, 2.49 MB

2020

44

Dimers of DNA-PK create a stage for DNA double-strand break repair

Chaplin, Amanda K., Hardwick, Steven W., Liang, Shikang, Kefala Stavridi, Antonia, Hnizda, Ales, Cooper, Lee R., De Oliveira, Taiana Maia, Chirgadze, Dimitri Y., Blundell, Tom L.

Journal:

Nature Structural and Molecular Biology

Year:

2020

File:

PDF, 10.66 MB

2020